Primary Causes & Action Plans
TNF-Alpha
Pro-inflammatory cytokine driving Th1 response in psoriasis TNF-alpha is elevated in psoriasis and drives inflammation. Anti-TNF therapies are effective for psoriasis.
Target < 2.4 pg/mL
Suggested Action Plan
Anti-TNF medications are effective but reserved for severe disease. Try anti-inflammatory diet and trigger elimination first.
hs-CRP
Marker of systemic inflammation Elevated in active psoriasis. Anti-inflammatory interventions reduce CRP and improve skin.
Target < 1.0 mg/L
Suggested Action Plan
Mediterranean diet, omega-3 supplementation, exercise reduce inflammation. Retest monthly.
Streptococcal Serology
Recent streptococcal infection can trigger psoriasis flares ASO titers identify recent strep infection, which can trigger guttate psoriasis. Treatment of strep may resolve psoriasis.
Target Negative
Suggested Action Plan
If positive ASO titer, confirm strep infection and treat. Psoriasis often improves after infection resolution.
Microbiome
Dysbiosis associated with impaired immune tolerance Dysbiosis allows pathogenic overgrowth. Restored dysbiosis improves immune tolerance and psoriasis.
Target Healthy diversity
Suggested Action Plan
Probiotics and prebiotic fiber improve psoriasis in many. Retest after 8-12 weeks.