Primary Causes & Action Plans
HbA1c
Blood sugar control; strong predictor of aging rate and lifespan HbA1c below 5.2% indicates excellent metabolic health and slower aging. Each 1% increase in HbA1c significantly increases mortality risk.
Target < 5.2%
Suggested Action Plan
Maintain or reduce HbA1c through low-carb diet, regular exercise, and weight management. This is the single most powerful intervention for slowing aging.
Fasting Insulin
Insulin resistance directly accelerates aging through multiple pathways Elevated fasting insulin is associated with faster aging, increased disease risk, and reduced lifespan. Lowering insulin is one of the most powerful anti-aging interventions.
Target < 5 uIU/mL
Suggested Action Plan
Reduce fasting insulin through carbohydrate restriction, intermittent fasting, and exercise. Aging rates improve measurably as insulin declines.
hs-CRP
Systemic inflammation directly drives aging through oxidative stress Chronic inflammation is the primary driver of aging and age-related disease. Low hs-CRP indicates slow aging; high indicates accelerated aging.
Target < 1.0 mg/L
Suggested Action Plan
Anti-inflammatory diet, exercise, sleep, and stress management all reduce hs-CRP and slow biological aging.
ApoB
Arterial plaque accumulation predicts cardiovascular aging and mortality Elevated ApoB indicates vascular aging. ApoB is one of the strongest predictors of cardiovascular mortality and overall aging trajectory.
Target < 80 mg/dL
Suggested Action Plan
Lower ApoB through diet, exercise, and weight loss. Statins are second-line if lifestyle is insufficient.
DHEA-S
Hormone of resilience and adaptation; declines with age and stress DHEA-S is a marker of adrenal resilience. Declining DHEA-S indicates accelerated aging and stress burden.
Target 150-350 mcg/dL (women); 250-450 (men)
Suggested Action Plan
Support DHEA-S through stress management, sleep, exercise. Some people benefit from low-dose DHEA supplementation (25-50 mg daily).