Primary Causes & Action Plans
ApoB
Single best predictor of lifespan and cardiovascular mortality ApoB is the strongest predictor of lifespan after age. Every 10 mg/dL reduction in ApoB reduces cardiovascular mortality significantly.
Target < 80 mg/dL (optimal)
Suggested Action Plan
Lower ApoB through Mediterranean diet, exercise, weight loss. This single intervention can extend lifespan by years.
HbA1c
Blood sugar control; strong predictor of overall mortality HbA1c below 5.2% predicts longest lifespan. Each 1% increase in HbA1c increases all-cause mortality significantly.
Target < 5.2%
Suggested Action Plan
Maintain excellent blood sugar control through diet and exercise. This is foundational to longevity.
Fasting Insulin
Inverse predictor of lifespan; low insulin associated with longevity Low fasting insulin is strongly associated with longevity. Every unit decrease in fasting insulin is associated with reduced mortality.
Target < 5 uIU/mL
Suggested Action Plan
Reduce insulin through carbohydrate restriction, intermittent fasting, and exercise. This is one of the most powerful longevity interventions.
hs-CRP
Chronic inflammation predicts mortality across all age groups hs-CRP below 1.0 mg/L is associated with longevity. Elevated hs-CRP is a strong mortality predictor.
Target < 1.0 mg/L
Suggested Action Plan
Anti-inflammatory lifestyle (Mediterranean diet, exercise, sleep, stress management) is the most powerful anti-aging intervention.
GGT (Gamma-Glutamyl Transferase)
Marker of oxidative stress and metabolic dysfunction; predicts mortality Elevated GGT indicates oxidative stress and poor metabolic health. Each unit increase in GGT increases mortality risk.
Target < 30 U/L
Suggested Action Plan
Lower GGT by reducing alcohol, improving liver health, and reducing oxidative stress through antioxidant-rich diet and exercise.