Hepatocyte Membrane Leakage

When liver cells (hepatocytes) are stressed by fat accumulation or toxins, their membranes become permeable, leaking ALT into the bloodstream. This is a primary signal of non-alcoholic steatohepatitis (NASH).

1

The Fructose Factor

Unlike glucose, fructose is processed almost entirely in the liver, making it the primary driver of elevated ALT.

2

Normal is not Healthy

The standard range for ALT has increased over decades as the population has become less healthy; 25 U/L is the true functional ceiling.

Optimal ALT Benchmarks

Functional Range (Metabolic Health Focused) 7 - 25 U/L
Standard Lab Range 7 - 52 U/L

Common Questions

Can exercise raise ALT?

Yes, intense weightlifting can cause a transient rise in ALT. It is best to test after 48 hours of rest.