Fibrinogen, Inflammation, and Clotting Risk
Fibrinogen is a large glycoprotein produced by hepatocytes in response to IL-6 stimulation. In the clotting cascade, thrombin converts fibrinogen to fibrin, which forms the structural framework of blood clots. Elevated fibrinogen increases blood viscosity, enhances platelet aggregation, and promotes fibrin deposition in arterial walls, all of which accelerate atherosclerosis. Chronically elevated fibrinogen creates a pro-thrombotic state that increases the risk of heart attack, stroke, and venous thromboembolism.
Cardiovascular Risk Factor
Elevated fibrinogen is an independent risk factor for cardiovascular events, adding predictive value beyond traditional cholesterol markers.
Blood Viscosity
Fibrinogen is the primary determinant of plasma viscosity. Elevated levels make blood thicker and more prone to clotting.
Optimal Fibrinogen Benchmarks
Common Questions
What causes high fibrinogen?
Chronic inflammation, smoking, obesity, diabetes, infection, and autoimmune disease all elevate fibrinogen. It rises as part of the acute-phase response to any inflammatory stimulus.
How can I lower fibrinogen?
Regular exercise, omega-3 fatty acids (EPA/DHA), nattokinase, smoking cessation, and anti-inflammatory diet can all help reduce fibrinogen levels.